AC Delco has not made a spark plug in over 20 years. Their plugs are made for them by NGK and... wait for it...
Champion.

It's true.
I love to drop that bomb on GM guys and just walk away, but the truth of it is that much like Mopar oil filters being made by Allied Signal but being better than Fram junk, Champion and NGK make the AC Delco plugs to AC's specifications. However, if you're curious the next time you have an AC plug in your hand, look for a row of slashes around the base below the hex: ////////////////. It goes all the way around the plug. That's a Champion Spark Plug "maker's mark" just like a finding a cast-in snowflake on an aluminum part means it was cast by Winters Foundries. If you see it on an AC plug it's defintely made by Champion.
Very important: Never use a cross-reference to determine what spark plug to put in your engine. Always use the catalog application guide. Spark-plug companies are full of smart people; it's not that they've never heard of (or forgot about) your dual-fuel 1957 Farmall D450. They just don't make a plug they feel is suitable for it, regardless of whether another manufacturer's plug crosses to it. If it's not in the application guide, choose a different brand.
Period.
As far as the EFI/carbureted thing, I've definitely had better luck with Champions in Chryslers (non-Mitsu) and ACs in GMs on both the carbureted and EFI end. Then again, the newest MPFI vehicle I've owned for any length of time is my '92 Dakota 3.9L. I will say this, though, I can't remember if my 340 Challenger ran worse with ACs than my 455 Pontiac ran with Champions, but in both cases the plugs were removed
the same day and replaced with what the factory recommended. It was literally
that bad.

I know Mopar guys from both eras that love Autolites; my experimentation with those many (over 20) years back on carbed engines kept me well dug into the "Champions in a Mopar" trenches. However, I've sold a ton of NGK and Denso platinums for GM applications simply due to cost. ACs are often twice as expensive as either. It's hard to sell $50 worth of spark plugs to a guy with a 17-year-old K1500. I've never had a problem or a complaint, so I would tend to agree that in the multi-port era, the differences are not as large.
On the flip side of that, if you own a
coil-on-plug Ford, I would highly advise you to use Motorcraft plugs
only. For whatever reason, Ford used very-specific coil drivers in many of their PCMs. Changing to a different brand of plug, even Autolite (who makes Motorcraft--again, that
doesn't mean they're the same), can and has burned up the coil drivers in the PCM. The 2004-06 Ford Escape/'05-'06 Mercury Mariner and Mazda Tribute with the 3.0 V6 were so bad, there were multiple Ford TSBs, some of which were withdrawn, dealing with those vehicles' appetite for PCMs. One of said TSBs regarded using only Motorcraft plugs in the engine. Sure enough, back in 2010 I sold a set of Autolites to a customer working on an '05 Escape, and a week later it was back in his shop with a dead miss on #1. It was a burned coil driver, and it turned into one of my biggest nightmares ever as a parts guy. To this day, those PCMs are "R&R only"--meaning you've got to send yours in for remanufacturing; good cores and junkyard PCMs don't exist.
Based on that experience alone, whatever the factory used is what I'm going to use. Things are only getting tweakier under the hood with each new model year.