Straight sixes generally don't rev as high as V8s (could change for specific engines being compared). The crank on a 6 cylinder is longer than the crank on a V8 (and much longer than a V6), and tends to start flexing/whipping around at lower rpm at lower RPM than a V8 or V6. This flexing/whipping tends to do bad things to the main bearings. I don't know what the actual rpm limits are, but the typical longer strokes on a straight 6 don't make the situation any better.
Kostas